By using a technique called RNA interference to screen thousands of genes, U.S. researchers have identified almost 300 human proteins that help HIV propagate, according to a new study.
This identification has created hope for new treatments to combat the HIV virus that causes AIDS, said the study conducted by a team of Harvard University researchers.
The team identified 273 human proteins which could provide a way to help people with HIV when the virus develops resistance to current antiviral drugs, according to the study published in the latest issue of Science Express. "Antiviral drugs are currently doing a good job of keeping people alive, but these therapeutics all suffer from the same problem, which is that you can get resistance, so we decided to take a different approach centered on the human proteins exploited by the virus. The virus would not be able to mutate to overcome drugs that interact with these proteins," senior author Stephen Elledge, a professor in Harvard Medical School's department of genetics, said in a prepared statement.
The expanded list of proteins gives future researchers "a hypothesis generation machine," he said.
"Scientists can look at the list, predict why HIV needs a particular protein, and then test their hypothesis," Elledge explained.
He noted that immune cells -- which are targeted by HIV -- contain high concentrations of many of the 273 proteins.
"We're closing in on a systems level understanding of HIV, which opens new therapeutic avenues. We might be able to tweak various parts of the system to disrupt (HIV) propagation without making our own cells sick," Elledge said.
(Xinhua News Agency January 13, 2008)
